Chitinase-3-like 1 regulates TH2 cells, TFH cells and IgE responses to helminth infection

This study identified the role of a protein called chitinase-3-like-1 (CHI3L1) in the immune response to nematode worm infection in mice. This is an important finding because previous studies have shown higher levels of this protein in the lungs and blood of people with asthma, and understanding how it affects immune response can lead to better treatment for asthma. First author Miranda Curtiss was funded by the AAAAI/American Lung Association Allergic Respiratory Disease Research Award.