Study Name:
RELIANCE (Roflumilast or azithromycin to prevent COPD exacerbations)
Targeted Disease(s):
COPD
Purpose of Study:
RELIANCE is multi-site pragmatic study to compare long-term roflumilast use with long-term azithromycin use in people who have COPD with chronic bronchitis who have been hospitalized in the past year. The team wants to learn how well these medicines work in preventing serious COPD episodes and understand the benefits and harms of long-term use. Studies have shown that the two drugs help reduce severe COPD episodes. Roflumilast is an anti-inflammatory medicine that can prevent serious COPD episodes and reduce hospital stays. Azithromycin is an antibiotic medicine used to treat serious COPD episodes and to reduce their frequency when taken long term. However, no studies have compared the two medicines to each other to see which works better for which patients. Patients must see their lung doctor to be enrolled in this study.
Study Dates:
June 1, 2019 - June 1, 2024
Study Design:
Controlled Design
Study Location:
Nationwide
Lead Institution:
University of Illinois at Chicago
Funding Source:
Patient-Centered Outcomes Research Institute (PCORI)
Sponsors:
Sponsorying institution: University of Illinois at Chicago; Funder: Patient-Centered Outcomes Research Institute (PCORI)
Contact:
Nina Bracken
[email protected]
ClinicalTrails.gov Identifier:
NCT04069312
